FSK HCl

FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo .


Cat. No.: EX-A9205A	Purity: >98%

	Chemical structure of FSK HCl

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	750	In-stock
100mg	get quote	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock
1g	get quote	Inquire

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Synonyms	FSK hydrochloride
CAS No.	3033987-42-4
Purity	>98%
Formula	C13H18ClFN2O6S
Mol Weight	384.808
Color	White to off-white
State	solid
Solubility	Soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Liu J, et al. A Genetically Encoded Fluorosulfonyloxybenzoyl-l-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry. J Am Chem Soc. 2021 Jul 14;143(27):10341-10351.
CoA	CoA of FSK HCl


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