FO-4-15

FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer's disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage.


Cat. No.: EX-A10059	Purity: >98%

	Chemical structure of FO-4-15

For research only, Do not use for Human!

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CAS No.	1030759-58-0
Purity	>98%
Formula	C18H20N4O4S
Mol Weight	388.441
Color	Off-white to light brown
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ for short term (days to weeks) or -20℃ for long term (months to years).; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Luo ZH, et al. Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway. Acta Pharmacol Sin. 2024 Aug 16.
CoA	CoA of FO-4-15

Smiles:	O=S(=O)(C1=CC=C(C=C1)C)N2CCN(CC3=NC(=NO3)C=4OC=CC4)CC2


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