Flucopride

Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h)5-HT4R). Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4R (EC50: 23.0 nM). Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay).


Cat. No.: EX-A12047	Purity: >98%

	Chemical structure of Flucopride

For research only, Do not use for Human!

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CAS No.	1639925-34-0
Purity	>98%
Formula	C22H33FN2O2
Mol Weight	376.508
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rochais C, et al. Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease. Eur J Med Chem. 2024 Dec 15;280:116975.
CoA	CoA of Flucopride

Smiles:	O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC2)CC3CCCCC3


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