FKB04

FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research.


Cat. No.: EX-A11998	Purity: >98%

	Chemical structure of FKB04

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	465	Inquire
100mg	712	Inquire
250mg	1056	Inquire
500mg	1556	Inquire
1g	get quote	Inquire

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CAS No.	108979-07-3
Purity	>98%
Formula	C17H15BrO4
Mol Weight	363.203
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Qiu, Yd., Yan, Q., Wang, Y. et al. Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells. Acta Pharmacol Sin 45, 1276–1286 (2024). https://doi.org/10.1038/s41401-024-01243-6
CoA	CoA of FKB04

Smiles:	O(C)C1=C(C(/C=C/C2=CC=C(Br)C=C2)=O)C(O)=CC(OC)=C1


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