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Product Information:

Filgotinib maleate

Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

Cat. No.: EX-A741A    Purity: >99%
Chemical
Chemical structure of Filgotinib maleate


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g425In-stock
5g1265In-stock
10mg2142In-stock
25gget quoteIn-stock
50gget quoteIn-stock


SynonymsGLPG0634 maleate
CAS No.1802998-75-9
Purity>99%
FormulaC25H27N5O7S
Mol Weight541.576
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1] Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191(7), 3568-3577.

[2] Merciris D, et al. P072 GLPG0634, the first selective JAK1 inhibitor, shows strong activity in the mouse DSS-colitis model. ECCO. 2014, P072.
CoACoA of Filgotinib maleate
Smiles:C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5.C(=C\C(=O)O)\C(=O)O

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