FIIN-1

FIIN-1 is a potent, irreversible, selective FGFR inhibitor. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC50s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively.


Cat. No.: EX-A14253	Purity: >98%

	Chemical structure of FIIN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	582	In-stock
100mg	795	In-stock
250mg	1098	In-stock
500mg	1568	In-stock
1g	2576	In-stock

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Synonyms	FGFR irreversible inhibitor-1
CAS No.	1256152-35-8
Purity	>98%
Formula	C32H39Cl2N7O4
Mol Weight	656.603
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wenjun Zhou, et al. A structure-guided approach to creating covalent FGFR inhibitors. Chem Biol. 2010 Mar 26;17(3):285-95.
CoA	CoA of FIIN-1

Smiles:	CCN(CC)CCCCNC1=NC=C2CN(C(=O)N(C2=N1)CC3=CC(=CC=C3)NC(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl


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