Fialuridine

Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively[1][2][3].


Cat. No.: EX-A14343	Purity: >98%

	Chemical structure of Fialuridine

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	232	In-stock
5g	788	In-stock
10g	960	In-stock
25g	1920	In-stock
50g	3072	In-stock
100g	4800	In-stock

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Synonyms	FIAU
Synonyms 2	DRG-0098
CAS No.	69123-98-4
Purity	>98%
Formula	C9H10FIN2O5
Mol Weight	372.089
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mansuri MM, et al. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71. [2]. Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord. 2005 Mar;5(1):17-28. [3]. Staschke KA, et al. The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Res. 1994 Jan;23(1):45-61. [4]. Richardson FC, et al. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12003-7.
CoA	CoA of Fialuridine

Smiles:	C1=C(C(=O)NC(=O)N1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)I


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