FGTI-2734 mesylate

FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.


Cat. No.: EX-A7763A	Purity: >98%

	Chemical structure of FGTI-2734 mesylate

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1100	1 week
100mg	1600	1 week
200mg	2400	1 week
500mg	get quote	1 week
1g	get quote	1 week

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CAS No.	2702297-24-1
Purity	>98%
Formula	C27H35FN6O5S2
Mol Weight	606.732
Color	White to off-white
State	solid powder
Solubility	DMSO : 75 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21.
CoA	CoA of FGTI-2734 mesylate

Smiles:	OS(=O)(C)=O.O=S(C1=NC=CC=C1)(N(CCN(C2=CC=C(C#N)C=C2F)CC3=CN=CN3C)CC4CCCCC4)=O


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