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Product Information:

FERb 033

FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1].

Cat. No.: EX-A14585    Purity: >98%
Chemical
Chemical structure of FERb 033


For research only, Do not use for Human!

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CAS No.1111084-78-6
Purity>98%
FormulaC13H9ClFNO3
Mol Weight281.667
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Filippo Minutolo, et al. Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem. 2009 Feb 12;52(3):858-67.

[2]. Satomi Kohno, et al. Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. Endocrinology. 2015 May;156(5):1887-99.

[3]. Sangeeta Bhallamudi, et al. Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L112-L124.

CoACoA of FERb 033
Smiles:C1=CC(=C(C=C1C2=C(C(=C(C=C2)/C=N/O)O)Cl)F)O

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