FEN1-IN-7

FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .


Cat. No.: EX-A7903	Purity: >98%

	Chemical structure of FEN1-IN-7

For research only, Do not use for Human!

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CAS No.	824983-90-6
Purity	>98%
Formula	C16H14N2O6S
Mol Weight	362.357
Color	White to off-white
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>1 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Tumey LN, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.
CoA	CoA of FEN1-IN-7


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