FAK-IN-22

FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively inhibiting tumor occurrence and metastasis in pancreatic ductal adenocarcinoma (PDAC). FAK-IN-22 effectively inhibits the proliferation of PANC-1 cells, with an IC50 value of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway.


Cat. No.: EX-A13508	Purity: >98%

	Chemical structure of FAK-IN-22

For research only, Do not use for Human!

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CAS No.	2703920-02-7
Purity	>98%
Formula	C21H16F3N5O2
Mol Weight	427.3792
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rong-Hong Zhang, et al. Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases. Eur J Med Chem. 2025 Jan 15:282:117059.
CoA	CoA of FAK-IN-22

Smiles:	O=C(NC)C1=CC=C(C=C1)NC2=NC=C(C(=N2)OC3=CC=CC=4NC=CC34)C(F)(F)F


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