FAK-IN-16

FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC50 of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice .


Cat. No.: EX-A15090	Purity: >98%

	Chemical structure of FAK-IN-16

For research only, Do not use for Human!

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CAS No.	1257994-15-2
Purity	>98%
Formula	C37H49F3N7O5P
Mol Weight	759.7978
Shipping	Please store the product under the recommended conditions in the Certificate of Analysis.

Reference:	[1]. Ingrid Moen, et al. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec;32(8):799-817.
CoA	CoA of FAK-IN-16

Smiles:	COC1=CC(CP(OCC)(OCC)=O)=CC=C1NC2=NC=C(C(F)(F)F)C(NC3=CC=C([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C(CN6C)=C3C6=O)=N2


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