Exatecan Mesylate

Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.


Cat. No.: EX-A2579	Purity: >99.9%

	Chemical structure of Exatecan Mesylate

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	250	In-stock
1g	350	In-stock
2g	500	In-stock
5g	1000	In-stock
10g	1800	In-stock
25g	3360	In-stock

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Synonyms	DX8951f
CAS No.	169869-90-3
Purity	>99.9%
Formula	C25H26FN3O7S
Mol Weight	531.553
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5. [3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.
CoA	CoA of Exatecan Mesylate

Smiles:	CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C4[C@@H](N)CCC5=C4C(=CC(F)=C5C)N=C13)C2=O


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