EW-7195

EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung.


Cat. No.: EX-A8358	Purity: >98%

	Chemical structure of EW-7195

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	438	in_stock
25mg	635	in_stock
50mg	954	in_stock
100mg	1360	in_stock
250mg	1865	in_stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	EW 7195
CAS No.	1352609-28-9
Purity	>98%
Formula	C23H18N8
Mol Weight	406.4426
Color	off-white to light yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Park CY, et al. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur J Cancer. 2011;47(17):2642-2653.
CoA	CoA of EW-7195

Smiles:	N#CC1=CC=CC(NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2)=C1


		Search