EV206

EV206 is a Hsp70 binder and apoptosis inducer that binds to the N-terminal domain of Hsp70, promotes Hsp70 degradation via the ubiquitin-proteasome system, and reduces Hsp70 protein stability. EV206 induces apoptotic cell death, inhibits colony formation, and downregulates the expression of cancer stem cell-related markers in non-small cell lung cancer cells. EV206 inhibits the growth of H460 xenograft tumors in nude mice and can be used for the research of non-small cell lung cancer.


Cat. No.: EX-A11493	Purity: >98%

	Chemical structure of EV206

For research only, Do not use for Human!

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CAS No.	2247047-81-8
Purity	>98%
Formula	C21H19N3O
Mol Weight	329.3951
Color	White to off-white
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Min HY, et al. Development of a novel N14-substituted antitumor evodiamine derivative with inhibiting heat shock protein 70 in non-small cell lung cancer. Sci Rep. 2024;14(1):25436. Published 2024 Oct 25.
CoA	CoA of EV206

Smiles:	O=C1C=2C=CC=CC2N(CC=C)C3C=4NC=5C=CC=CC5C4CCN13


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