Etomoxir

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.


Cat. No.: EX-A10499	Purity: >98%

	Chemical structure of Etomoxir

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	896	In-stock
1g	1598	In-stock
2g	2560	In-stock
5g	4872	In-stock
10g	get quote	In-stock

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Synonyms	(R)-(+)-Etomoxir
CAS No.	124083-20-1
Purity	>98%
Formula	C17H23ClO4
Mol Weight	326.815
Color	colorless to light yellow
State	<32? Solid,>34? Liqu
Solubility	soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	4℃ protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rupp H, et al. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz. 2002 Nov;27(7):621-36. [2]. Xu FY, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23. [3]. Li J, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015 Jul 31;5:12724. [4]. Luiken JJ, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447-55. [5]. O'Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289.
CoA	CoA of Etomoxir

Smiles:	O=C(OCC)[C@@]1(OC1)CCCCCCOC2=CC=C(C=C2)Cl


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