ERK12 inhibitor 10

ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC50: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations .


Cat. No.: EX-A16320	Purity: >98%

	Chemical structure of ERK12 inhibitor 10

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
500mg	get quote	inquire
1g	get quote	inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	3056077-07-4
Purity	>98%
Formula	C23H20ClN5O2S
Mol Weight	465.955
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shuai W, et al. Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors. J Med Chem. 2024 Apr 25;67(8):6425-6455.
CoA	CoA of ERK12 inhibitor 10

Smiles:	O=C(C1=CC(C2=NC(NC3=CC=NC(C)=C3)=NC=C2Cl)=CS1)N[C@@H](C4=CC=CC=C4)CO


		Search