ERBB agonist-1

ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC50 of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H2O2-induced cardiomyocyte death and Ang II-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models.


Cat. No.: EX-A12888	Purity: >98%

	Chemical structure of ERBB agonist-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	500	In-stock
100mg	800	In-stock
250mg	1580	In-stock
500mg	2600	In-stock
1g	4200	In-stock
2g	6700	In-stock

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CAS No.	930856-19-2
Purity	>98%
Formula	C24H25N3O2S
Mol Weight	419.539
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cools JMT, et al., Small-molecule-induced ERBB4 activation to treat heart failure. Nat Commun. 2025 Jan 10;16(1):576.
CoA	CoA of ERBB agonist-1

Smiles:	O=C(NC1CC1)C(SC(N2C3CCCC3)=NC4=CC=CC=C4C2=O)C5=CC=CC=C5


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