ERAS-0015

Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects.


Cat. No.: EX-A9620	Purity: >98%

	Chemical structure of ERAS-0015

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	725	In-stock
500mg	1125	In-stock
1g	1900	In-stock
2g	2900	In-stock
3g	4800	In-stock
5g	7500	In-stock

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CAS No.	3034673-92-9
Purity	>98%
Formula	C46H60N8O5S
Mol Weight	837.084
Color	white to light yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Y Zhang, et al. Macrocyclic derivative and use thereof. WO2024067857A1. 2023-09-28
CoA	CoA of ERAS-0015

Smiles:	O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C=4C=C(C=NC4C(OC)C)N5CCN(C)CC5)CC)C=6N=C(SC6)CC(NC(=O)C7C(C)C7C)C(=O)N8NC1C9CC8C9


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