EPZ020411 HCl

EPZ020411 hydrochloride is a selective inhibitor of PRMT6 with an IC50 of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer .


Cat. No.: EX-A1601A	Purity: >98%

	Chemical structure of EPZ020411 HCl

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	1450	in-stock
500mg	2050	in-stock
1g	2885	in-stock

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Synonyms	EPZ020411 hydrochloride
CAS No.	2070015-25-5
Purity	>98%
Formula	C25H39ClN4O3
Mol Weight	479.055
Color	Off-white to light yellow
State	solid
Solubility	soluble in H2O/DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃,stored under nitrogen, 1 year; In solvent -20℃, 6 months;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6(6):655-659. [2]. He Y, et al. Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics. 2020 Jan 1;10(1):133-150.
CoA	CoA of EPZ020411 HCl

Smiles:	CNCCN(C)CC1=CNN=C1C2=CC=C(O[C@H]3C[C@H](OCCC4CCOCC4)C3)C=C2.Cl[H]


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