EP652

EP652 is a METTL3 inhibitor and antitumor agent with IC50 values of 2 nM, <10 nM, and 37 nM in SPA, intracellular, and ATPlite assays, respectively. EP652 exhibits high selectivity against 40 other methyltransferases and FTO, and possesses favorable pharmacokinetic parameters. EP652 reduces intracellular N6-methyladenosine (m6A) levels in mRNA. EP652 inhibits tumor growth and progression of both hematologic malignancies and solid tumors. EP652 can be used for the research of acute myeloid leukemia, ovarian cancer, non-small cell lung cancer, and hypopharyngeal squamous cell carcinoma.


Cat. No.: EX-A12521	Purity: >98%

	Chemical structure of EP652

For research only, Do not use for Human!

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CAS No.	3050819-22-9
Purity	>98%
Formula	C25H34N8O
Mol Weight	462.5905
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Dutheuil G, et al. Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models. J Med Chem. 2025;68(3):2981-3003.
CoA	CoA of EP652

Smiles:	[C@H](C)(N1C=C(N=N1)C=2C=C(N(C)C)C=NC2)N3C(=O)C=C(C=C3)N4C[C@H](NCC5CC5)CCC4


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