Enpatoran hydrochloride

Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research.


Cat. No.: EX-A5509A	Purity: >98%

	Chemical structure of Enpatoran hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	385	in-stock
100mg	585	in-stock
250mg	900	in-stock
500mg	1600	in-stock
1g	2800	in-stock
5g	7600	in-stock

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Synonyms	M5049 hydrochloride
CAS No.	2101945-93-9
Purity	>98%
Formula	C16H16ClF3N4
Mol Weight	356.773
Color	Light yellow to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, away from moisture, 2 year; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jaromir Vlach, et al. Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity. J Pharmacol Exp Ther. 2020 Dec 16;JPET-AR-2020-000275.
CoA	CoA of Enpatoran hydrochloride

Smiles:	C1[C@@H](CN(C[C@@H]1N)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F.Cl


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