EN450

EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.


Cat. No.: EX-A7945F	Purity: >98%

	Chemical structure of EN450

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	185	In-stock
25mg	350	In-stock
50mg	500	In-stock
100mg	700	In-stock
200mg	1000	In-stock

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CAS No.	793719-01-4
Purity	>98%
Formula	C11H13ClN2O3S
Mol Weight	288.751
Color	White to off-white
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. King EA, et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem Biol. 2023 Apr 20;30(4):394-402.e9.
CoA	CoA of EN450


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