EMD 66684

EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC50 value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant.


Cat. No.: EX-A14179	Purity: >98%

	Chemical structure of EMD 66684

For research only, Do not use for Human!

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CAS No.	1216884-39-7
Purity	>98%
Formula	C28H31ClN8O2
Mol Weight	547.051
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Westfall TC, et al. Interactions of neuropeptide y, catecholamines, and angiotensin at the vascular neuroeffector junction. Adv Pharmacol. 2013;68:115-39. [2]. Qu L, et al. Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. J Pharmacol Toxicol Methods. 2020 Mar-Apr;102:106682. [3]. Mederski WW, et al. Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J Med Chem. 1994 May 27;37(11):1632-45. [4]. Byku M, et al. Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2188-97. [5]. Avkran M, et al. Treatment of ischemia with an angiotensin II antagonist: UK, GB2337701. 1999-12-01.
CoA	CoA of EMD 66684

Smiles:	CCCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)N(C=C2)CC(=O)N(C)C.Cl


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