eIF4A3-IN-1

eIF4A3-IN-1 is a selective eIF4A3 inhibitor (IC50: 0.26 μM; Kd: 0.043 μM) with cellular nonsense-mediated RNA decay (NMD) inhibitory activity. eIF4A3-IN-1 can specifically bind to the non-ATP binding site of eIF4A3. eIF4A3-IN-1 has anti-tumor and analgesic activities.


Cat. No.: EX-A8462	Purity: >98%

	Chemical structure of eIF4A3-IN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1850	In-stock
250mg	2850	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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CAS No.	2095486-67-0
Purity	>98%
Formula	C29H23BrClN5O2
Mol Weight	588.882
Color	white to off-white
State	solid powder
Solubility	DMSO : 200 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60(8):3335-3351. [2]. López-Cánovas JL, et al. Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing. Clin Transl Med. 2022 Nov;12(11):e1102. [3]. Hsieh MC, et al. Phosphorylated Upstream Frameshift 1-dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia-like Behavior in Rats. Anesthesiology. 2023 Jun 1;138(6):634-655.
CoA	CoA of eIF4A3-IN-1

Smiles:	O=C(C1=CC=C(C=C1)Br)N2[C@@H](C3=CC=C(C=C3)Cl)CN(CC2)C(C4=C(N(C5=CC(C#N)=CC=C5)N=C4)C)=O


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