Eggmanone

Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade.


Cat. No.: EX-A14260	Purity: >98%

	Chemical structure of Eggmanone

For research only, Do not use for Human!

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CAS No.	505068-32-6
Purity	>98%
Formula	C20H20N2O2S3
Mol Weight	416.58
Color	White to off-white
State	Solid
Solubility	DMSO : 10 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Williams CH, et al. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 2015;11(1):43-50.
CoA	CoA of Eggmanone

Smiles:	CC(=C)CN1C(=O)C2=C(N=C1SCC(=O)C3=CC=CS3)SC4=C2CCCC4


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