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Product Information:

EGFRHER2-IN-7

EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM) .

Cat. No.: EX-A16114    Purity: >98%
Chemical
Chemical structure of EGFRHER2-IN-7


For research only, Do not use for Human!

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CAS No.2820126-28-9
Purity>98%
FormulaC19H21N3O2S
Mol Weight355.454
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.

CoACoA of EGFRHER2-IN-7
Smiles:CC1=CC=C(C=C1)C2=C(N=C3N2C(=CS3)C(=O)O)CN4CCCCC4

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