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Product Information:

EGFR-IN-78

EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase.

Cat. No.: EX-A12192    Purity: >98%
Chemical
Chemical structure of EGFR-IN-78


For research only, Do not use for Human!

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CAS No.3042104-73-1
Purity>98%
FormulaC23H32BrN7O2S
Mol Weight550.515
ColorWhite to light yellow
StateSolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mao YZ, et al. Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129381.

CoACoA of EGFR-IN-78

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