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Product Information:

EGFR-IN-5

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Cat. No.: EX-A14748    Purity: >98%
Chemical
Chemical structure of EGFR-IN-5


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg604In-stock
500mg994In-stock
1g1760In-stock


CAS No.2225887-26-1
Purity>98%
FormulaC31H38FN9O
Mol Weight571.6915
ColorLight yellow to yellow
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

CoACoA of EGFR-IN-5
Smiles:CN(C)C1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C(=C3)C(=NC(=N4)NC5=CC=C(C=C5)F)N6CCC(CC6)CO

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