EGFR/HER2-IN-12

EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant


Cat. No.: EX-A17339	Purity: >98%

	Chemical structure of EGFR/HER2-IN-12

For research only, Do not use for Human!

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CAS No.	2237230-21-4
Purity	>98%
Formula	C25H17ClN4O3S
Mol Weight	488.945

Reference:	[1].Milik SN, et al. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Eur J Med Chem. 2018 Jul 15;155:316-336.
CoA	CoA of EGFR/HER2-IN-12

Smiles:	O=[N+]([O-])C1=CC=C(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OC5=CC=CC(C)=C5)N=CN=C3S2)C=C1


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