EGFR/HER2/DHFR-IN-1

EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC50s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis.


Cat. No.: EX-A12168	Purity: >98%

	Chemical structure of EGFR/HER2/DHFR-IN-1

For research only, Do not use for Human!

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CAS No.	2820126-37-0
Purity	>98%
Formula	C14H11BrN4O2S
Mol Weight	379.232
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.
CoA	CoA of EGFR/HER2/DHFR-IN-1


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