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Product Information:

EGFR/AURKB-IN-1

EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research.

Cat. No.: EX-A8957    Purity: >98%
Chemical
Chemical structure of EGFR/AURKB-IN-1


For research only, Do not use for Human!

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CAS No.3008543-34-5
Purity>98%
FormulaC23H20N6O
Mol Weight396.4445
ColorOff-white to light yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kurup S, et al. Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer. Bioorg Med Chem Lett. 2024 Jan 8:129612.

CoACoA of EGFR/AURKB-IN-1
Smiles:CN1N=CC=C1C2=CC3=C(N=CN=C3N2)NC4=CC=C(C=C4)OCC5=CC=CC=C5

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