EC359

EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a Kd of 10.2 nM, which directly interacts with LIFR to effectively block LIF/LIFR interactions.


Cat. No.: EX-A3367	Purity: >98%

	Chemical structure of EC359

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	850	In-stock
50mg	1150	In-stock
100mg	1850	In-stock
1g	get quote	Inquire

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Synonyms	EC-359
CAS No.	2012591-09-0
Purity	>98%
Formula	C36H38F2O2
Mol Weight	540.6825
State	solid powder
Solubility	DMSO >100mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Viswanadhapalli S, et al. EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. 2019 Aug;18(8):1341-1354.
CoA	CoA of EC359

Smiles:	C[C@@]12[C@](O)(C(F)(F)C#C)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(C6=C(C)C=C(C)C=C6C)C=C5)C2)=O


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