EAI-045

EAI045 is an allosteric and the fourth-generation inhibitor of mutant EGFR with IC50s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFRL858R, EGFRT790M and EGFRL858R/T790M at 10 μM ATP, respectively.


Cat. No.: EX-A1735	Purity: >98%

	Chemical structure of EAI-045

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	285	In-stock
1g	485	In-stock
5g	885	In-stock
10g	1385	In-stock
25g	1985	In-stock

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Synonyms	EAI045
CAS No.	1942114-09-1
Purity	>98%
Formula	C19H14FN3O3S
Mol Weight	383.396
Color	white to off-white
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jia Y, et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016 Jun 2;534(7605):129-32. [2]. Wang S, et al. EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance. Cancer Lett. 2017 Jan 28;385:51-54.
CoA	CoA of EAI-045

Smiles:	OC1=C(C=C(F)C=C1)C(N1CC2=CC=CC=C2C1=O)C(=O)NC1=NC=CS1


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