E2012

E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat[1].


Cat. No.: EX-A15375	Purity: >98%

	Chemical structure of E2012

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	588	in-stock
250mg	896	in-stock
500mg	1296	in-stock
1g	1896	in-stock

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Synonyms	(E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-Methoxy-4-(4-Methyl-1H-iMidazol-1-yl)benzylidene]piperidin-2-one
Synonyms 2	E 2012
CAS No.	870843-42-8
Purity	>98%
Formula	C25H26FN3O2
Mol Weight	419.4912
Color	Light yellow to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 year;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137(1):249-58. [2]. Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K.Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.J Alzheimers Dis. 2010;21(3):1005-12.
CoA	CoA of E2012

Smiles:	CC1=CN(C=N1)C2=C(C=C(C=C2)/C=C/3\CCCN(C3=O)[C@@H](C)C4=CC=C(C=C4)F)OC


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