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Product Information:

DXR-IN-3

DXR-IN-3 is a DXR inhibitor that specifically targets Toxoplasma gondii. DXR-IN-3 shows in vitro activity against the TgDXR enzyme, with an IC50 value of 0.62 μM and a Ki value of 0.19 μM. DXR-IN-3 can inhibit the proliferation of Toxoplasma, with an IC50 value of 5.46 μM.

Cat. No.: EX-A12800    Purity: >98%
Chemical
Chemical structure of DXR-IN-3


For research only, Do not use for Human!

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CAS No.1465907-72-5
Purity>98%
FormulaC10H12Cl2NO5PS
Mol Weight360.151
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mazzone F, et al. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors. Biochem J. 2024 Aug 21;481(16):1075-1096.

CoACoA of DXR-IN-3
Smiles:O=C(N(C)O)CSC(P(O)(O)=O)C1=CC(Cl)=C(Cl)C=C1

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