DWIZ-2

DWIZ-2 is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys .


Cat. No.: EX-A9597	Purity: >98%

	Chemical structure of DWIZ-2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	786	In-stock
250mg	1182	In-stock
500mg	1882	In-stock
1g	2900	In-stock

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CAS No.	2654011-51-3
Purity	>98%
Formula	C21H27N3O4
Mol Weight	385.4568
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ting PY, et al., A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science. 2024 Jul 5;385(6704):91-99.
CoA	CoA of DWIZ-2

Smiles:	O=C1N(CC=2C1=CC=C(OC[C@@H]3N(CC)CCCC3)C2)C4C(=O)NC(=O)CC4


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