Duocarmycin DM free base

Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.


Cat. No.: EX-A12593	Purity: >98%

	Chemical structure of Duocarmycin DM free base

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1mg	320	In-stock
5mg	550	In-stock
10mg	880	In-stock
25mg	1750	In-stock
50mg	2800	In-stock
100mg	4500	In-stock

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CAS No.	1116745-06-2
Purity	>98%
Formula	C26H26ClN3O3
Mol Weight	463.956
Color	Light yellow to green yellow
State	solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, stored under nitrogen; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630. [2]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4. [3]. Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782. [4]. Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.
CoA	CoA of Duocarmycin DM free base

Smiles:	C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(OCCN(C)C)C4)C1)C=C(O)C=5C2=CC=CC5


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