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Product Information:

Dual Cathepsin L/JAK-IN-1

Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI).

Cat. No.: EX-A12201    Purity: >98%
Chemical
Chemical structure of Dual Cathepsin L/JAK-IN-1


For research only, Do not use for Human!

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CAS No.2450279-41-9
Purity>98%
FormulaC19H18ClN5
Mol Weight351.833
ColorLight yellow to green yellow
StateSolid
SolubilityDMSO : 7.14 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Shen C,et al. Design, Synthesis, and Biological Evaluation of 2-Arylaminopyrimidine Derivatives as Dual Cathepsin L and JAK Inhibitors for the Treatment of Acute Lung Injury. J Med Chem. 2025 Jan 9;68(1):361-386.

CoACoA of Dual Cathepsin L/JAK-IN-1

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