DPI-4452

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models.


Cat. No.: EX-A15652	Purity: >98%

	Chemical structure of DPI-4452

For research only, Do not use for Human!

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CAS No.	2941391-49-5
Purity	>98%
Formula	C92H132N22O29S3
Mol Weight	2106.357
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, sealed storage, away from moisture and light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. 1. Massière, et al. Preclinical Characterization of DPI-4452: A68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024, 65(5), 761–767.
CoA	CoA of DPI-4452

Smiles:	C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N3CCC[C@@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(C)C)CC4=CC(=CC=C4)NC(=O)CCCS(=O)(=O)N)CC(=O)O)CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)CN5CCN(CC5)C(=O)CN6CC


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