DP-15

DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models.


Cat. No.: EX-A13702	Purity: >98%

	Chemical structure of DP-15

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	398	In-stock
25mg	598	In-stock
50mg	998	In-stock
100mg	1888	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	Dual GSPT1/BRD4 degrader DP-15
CAS No.	3033837-71-4
Purity	>98%
Formula	C42H44ClN9O5S
Mol Weight	822.374
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xu Y, et al., Discovery of highly potent dual GSPT1/BRD4 degraders with anti-AML activity. Eur J Med Chem. 2025 Apr 15;288:117381.
CoA	CoA of DP-15

Smiles:	CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)C9=NN=C(C)N29


		Search