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Doxorubicin-MVCP

Doxorubicin-MVCP, also known as MC-Val-Cit-PAB-Doxorubicin, is a Doxorubicin derivative with a MC-Val-Cit-PAB linker. Mc-Val-Cit-PAB is a cathepsin cleavable ADC peptide linker. Doxorubicin-MVCP can be used to conjugate with other molecules such as peptides, proteins, antibodies or enzymes, or polymers. Doxorubicin-MVCP is a useful agent to make Doxorubicin-conjugate for drug delivery, nanodrug research.

Cat. No.: EX-A5150    Purity: >98%
Chemical
Chemical structure of Doxorubicin-MVCP


For research only, Do not use for Human!

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SynonymsMC-Val-Cit-PAB-Doxorubicin
Synonyms 2MC-Val-Cit-PAB-Dox
Purity>98%
FormulaC56H67N7O19
Mol Weight1142.1667
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Wu DC, et al. Preparation, drug release, and cell growth inhibition of a gelatin: doxorubicin conjugate. Pharm Res. 2013 Aug;30(8):2087-96. PMID: 23686374.

[2]. She W, et al. Dendronized heparin-doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy. Biomaterials. 2013 Mar;34(9):2252-64. PMID: 23298778.

[3]. Schoener CA, et al. An inulin and doxorubicin conjugate for improving cancer therapy. J Drug Deliv Sci Technol. 2013;23(2):111-118. PubMed PMID: 24734120; PubMed Central PMCID: PMC3984582.

[4]. Ye WL, et al. Synthesis of a new pH-sensitive folate-doxorubicin conjugate and its antitumor activity in vitro. J Pharm Sci. 2013 Feb;102(2):530-40. PMID: 23169439.

[5]. Huan M, et al. In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. Biosci Biotechnol Biochem. 2012;76(8):1577-9. Epub 2012 Aug 7. PubMed PMID: 22878199.
CoACoA of Doxorubicin-MVCP

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