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Product Information:

DOTA-XYIMSR-01

DOTA-XYIMSR-01 is a molecular probe targeting CAIX that can be labeled with 177Lu for the inhibition and localization of malignant gliomas. The uptake of [177Lu] Lu-XYIMSR-01 in U87MG tumors is 6.19 % of the injected dose per gram (% ID/g), and the tumor-to-muscle uptake ratio is 20.14. In the orthotopic glioma model, combined injection with Temozolomide can significantly improve the survival rate of mice and inhibit tumor growth. DOTA-XYIMSR-01 shows promise for research in the field of anti-cancer therapy .

Cat. No.: EX-A15835    Purity: >98%
Chemical
Chemical structure of DOTA-XYIMSR-01


For research only, Do not use for Human!

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CAS No.2051527-54-7
Purity>98%
FormulaC61H88N16O22S2
Mol Weight1461.575
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Wang J, et al. [177Lu]Lu-XYIMSR-01: A Novel CAIX-Targeted Radiotherapeutic for Enhanced Treatment of Malignant Glioma. Bioconjug Chem. 2025 Mar 19;36(3):588-596.

CoACoA of DOTA-XYIMSR-01
Smiles:C(CCC(N[C@@H](CC(N[C@@H](CC(N[C@@H](CCCCN1C=C(CCCC(NC=2SC(S(N)(=O)=O)=NN2)=O)N=N1)C(NCCOCCOCCNC(CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3)=O)=O)=O)C(O)=O)=O)C(O)=O)=O)(C)(C4=CC=C(O)C=C4)C5=CC=C(O)C=C5

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