Dolastatin 10 trifluoroacetate

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.


Cat. No.: EX-A8176	Purity: >98%

	Chemical structure of Dolastatin 10 trifluoroacetate

For research only, Do not use for Human!

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CAS No.	2342568-65-2
Purity	>98%
Formula	C44H69F3N6O8S
Mol Weight	899.114
State	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bai RL, Pettit GR, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J Biol Chem. 1990 Oct 5;265(28):17141-9. PMID: 2211617. [1]. Bai R, Taylor GF, Schmidt JM, Williams MD, Kepler JA, Pettit GR, Hamel E. Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol Pharmacol. 1995 May;47(5):965-76. PMID: 7746283.
CoA	CoA of Dolastatin 10 trifluoroacetate

Smiles:	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C.C(=O)(C(F)(F)F)O


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