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Product Information:

DNA-PK-IN-12

DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC50 of 33.28 μM, and shows antitumor activity in vivo .

Cat. No.: EX-A9642    Purity: >98%
Chemical
Chemical structure of DNA-PK-IN-12


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg525in_stock
50mg860in_stock
100mg1372in_stock


CAS No.2792146-91-7
Purity>98%
FormulaC21H24N8O2
Mol Weight420.4677
ColorLight brown to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Liu K, et al. Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. J Med Chem. Published online December 20, 2023.

CoACoA of DNA-PK-IN-12
Smiles:O=C1N(C2=CN=C(N=C2N1C3CCOCC3)NC=4C=NC(=CC4C)C=5C=NN(C5)C)C

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