DNA crosslinker 6

DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei .


Cat. No.: EX-A10525	Purity: >98%

	Chemical structure of DNA crosslinker 6

For research only, Do not use for Human!

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CAS No.	272791-87-4
Purity	>98%
Formula	C19H21N7O
Mol Weight	363.4163
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nué-Martinez J J, et al. Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs[J]. Scientific Reports, 2024, 14(1): 26173.
CoA	CoA of DNA crosslinker 6

Smiles:	O=C(NC1=CC=C(C=C1)NC2=NCCN2)C3=CC=C(C=C3)NC4=NCCN4


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