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Product Information:

DN401

DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90). DN401 exhibited potent anticancer activity.

Cat. No.: EX-A8832    Purity: >98%
Chemical
Chemical structure of DN401


For research only, Do not use for Human!

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SynonymsPanvotinib-401
Synonyms 2Pan-401
CAS No.2135749-60-7
Purity>98%
FormulaC13H9BrClN5O2
Mol Weight382.6
ColorOff-white to light yellow
Statesolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Park, Hye-Kyung et al. “Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.” Journal of medicinal chemistry vol. 60,17 (2017): 7569-7578. doi:10.1021/acs.jmedchem.7b00978

[2]. Kim, Darong et al. “Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.” Bioorganic chemistry vol. 101 (2020): 103901. doi:10.1016/j.bioorg.2020.103901

CoACoA of DN401

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