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Product Information:

DM4

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.

Cat. No.: EX-A3441    Purity: >98%
Chemical
Chemical structure of DM4


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg812In-stock
500mg1495In-stock
1g1998In-stock
5gget quoteIn-stock
10gget quoteIn-stock
20gget quoteIn-stock


SynonymsDM-4
Synonyms 2Ravtansine
CAS No.796073-69-3
Purity>98%
FormulaC38H54ClN3O10S
Mol Weight780.367
Colorwhite to light yellow
Statesolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

CoACoA of DM4
Smiles:C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

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