DLK-IN-2

DLK-IN-2 is a selective inhibitor of DLK and neuroprotective agent. DLK-IN-2 shows no significant inhibition against CYPs 3A4, 2D6 and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent pro-degenerative axon-to-soma retrograde signaling and suppresses c-Jun phosphorylation. DLK-IN-2 can be used for the mechanistic study of neurodegenerative diseases .


Cat. No.: EX-A16661	Purity: >98%

	Chemical structure of DLK-IN-2

For research only, Do not use for Human!

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25mg	get quote

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CAS No.	883012-32-6
Purity	>98%
Formula	C23H25ClN2O3S
Mol Weight	444.974

Reference:	[1].Zhang X, et al. Combinatorial chemistry identifies additional compounds that selectively inhibit DLK-dependent retrograde signaling while minimally affecting other axonal roles of DLK. Sci Rep. 2026;16(1):3892. Published 2026 Jan 27.
CoA	CoA of DLK-IN-2

Smiles:	O=C(NC1=CC=C(C=C1)S(=O)(=O)NC23CC4CC(CC(C4)C2)C3)C5=CC=C(Cl)C=C5


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