DL-Thiorphan

Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .


Cat. No.: EX-A17507	Purity: >98%

	Chemical structure of DL-Thiorphan

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	399	in_stock
500mg	637	in_stock
1g	997	in_stock
2g	1642	in_stock
3g	1971	in_stock
5g	2648	in_stock

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CAS No.	76721-89-6
Purity	>98%
Formula	C12H15NO3S
Mol Weight	253.317
Color	White to off-white
State	Solid
Solubility	DMSO : 175 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Whyteside AR, et al. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6. [2]. Cheung D, et al. The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. Am Rev Respir Dis. 1992 Jun;145(6):1275-80. [3].Medja F, et al. Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain. 2006 Dec;129(Pt 12):3209-23.
CoA	CoA of DL-Thiorphan

Smiles:	SCC(C(NCC(O)=O)=O)CC1=CC=CC=C1


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